ViRBase: a resource for virus–host ncRNA-associated interactions

Li, Yanhui; Wang, Changliang; Miao, Zhengqiang; Bi, Xiaoman; Wu, Deng; Jin, Nana; Wang, Liqiang; Wu, Hao; Qian, Kun; Li, Chunhua; Zhang, Ting; Zhang, Chunrui; Yi, Ying; Lai, Hongyan; Hu, Yongfei; Cheng, Lixin; Prof. LEUNG Kwong Sak; Li, Xiaobao; Zhang, Fengmin; Li, Kongning

doi:10.1093/nar/gku903

ViRBase: a resource for virus–host ncRNA-associated interactions

Date Issued

2015

Journal

Nucleic Acids Research

ISSN

1362-4962

Citation

Nucleic Acids Research, 2015,, Volume 43 (D1) , pp. D578–D582,

DOI

10.1093/nar/gku903

URI

http://hdl.handle.net/20.500.11861/7484

Type

Peer Reviewed Journal Article

Abstract

Increasing evidence reveals that diverse non-coding RNAs (ncRNAs) play critically important roles in viral infection. Viruses can use diverse ncRNAs to manipulate both cellular and viral gene expression to establish a host environment conducive to the completion of the viral life cycle. Many host cellular ncRNAs can also directly or indirectly influence viral replication and even target virus genomes. ViRBase (http://www.rna-society.org/virbase) aims to provide the scientific community with a resource for efficient browsing and visualization of virus-host ncRNA-associated interactions and interaction networks in viral infection. The current version of ViRBase documents more than 12 000 viral and cellular ncRNA-associated virus–virus, virus–host, host–virus and host–host interactions involving more than 460 non-redundant ncRNAs and 4400 protein-coding genes from between more than 60 viruses and 20 hosts. Users can query, browse and manipulate these virus–host ncRNA-associated interactions. ViRBase will be of help in uncovering the generic organizing principles of cellular virus–host ncRNA-associated interaction networks in viral infection.

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ViRBase: a resource for virus–host ncRNA-associated interactions

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