Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.11861/7512
Title: Non-invasive assessment of liver fibrosis with transient elastography (FibroScan®): Applying the cut-offs of M probe to XL probe
Authors: Wong, Grace Lai-Hung 
Vergniol, Julien 
Lo, Peter 
Wong, Vincent Wai-Sun 
Foucher, Juliette 
Le Bail, Brigitte 
Choi, Paul Cheung-Lung 
Chermak, Faiza 
Prof. LEUNG Kwong Sak 
Merrouche, Wassil 
Chan, Henry Lik-Yuen 
de Lédinghen, Victor 
Issue Date: 2013
Publisher: Fundacion Clinica Medica Sur
Source: Annals of Hepatology , 12(4), pp. 402-412
Journal: Annals of Hepatology 
Abstract: Background and rationale for the study. Limited studies have aimed to define the cut-offs of XL probe (XL cut-offs) for different stages of liver fibrosis, whereas those of M probe (M cut-offs) may not be applicable to XL probe. We aimed to derive appropriate XL cut-offs in overweight patients. Patients with liver stiffness measurement (LSM) by both probes were recruited. XL cut-offs probe for corresponding M cut-offs were derived from an exploratory cohort, and subsequently validated in a subgroup patients also underwent liver biopsy. The diagnostic accuracy of XL cut-offs to diagnose advanced fibrosis was evaluated. Results. Total 517 patients (63% male, mean age 58) who had reliable LSM by both probes were included in the exploratory cohort. There was a strong correlation between the LSM by M probe (LSM-M) and LSM by XL probe (LSM-XL) (r2 = 0.89, p < 0.001). A decision tree using LSM-XL was learnt to predict the 3 categories of LSM-M (< 6.0kPa, 6.0-11.9kPa and ≥ 12.0kPa), and XL cut-offs at 4.8kPa and 10.7kPa were identified. These cut-offs were subsequently validated in a cohort of 147 patients who underwent liver biopsy. The overall accuracy was 89% among 62 patients whose LSM-XL < 4.8kPa or ≥ 10.7kPa. These cut-offs would have avoided under-staging of fibrosis among patients with body mass index (BMI) > 25-30 kg/m2 but not > 30 kg/m2. Conclusions. XL cut-offs at 4.8kPa and 10.7kPa were the best estimates of 6.0kPa and 12.0kPa of M probe for patients with BMI > 25-30 kg/m2. Patients with BMI > 30 kg/m2 might use M probe cut-offs for XL probe.
Type: Peer Reviewed Journal Article
URI: http://hdl.handle.net/20.500.11861/7512
ISSN: 16652681
DOI: 10.1016/s1665-2681(19)31341-9
Appears in Collections:Applied Data Science - Publication

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