Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.11861/7156
Title: Gray matter asymmetry in the orbitofrontal cortex in relation to psychopathic traits in adolescents
Authors: Dr. LAM Yin-Hung, Bess 
Huang, Yonglin 
Gao, Yu 
Issue Date: 2021
Source: Journal of Psychiatric Research, Jan 2021, vol. 132, pp. 84-96.
Journal: Journal of Psychiatric Research 
Abstract: Background Structural abnormalities in the orbitofrontal cortex (OFC) of incarcerated psychopaths have been well documented. However, the neural correlates of psychopathic traits in younger and nonclinical samples remain poorly understood. Aim The present study aimed to examine the structural brain asymmetry in the OFC in relation to dimensions of psychopathic traits in adolescents from the community. Method In 29 youths from the community, childhood psychopathic traits including narcissism, impulsivity, and callous-unemotional traits were assessed when they were 7- to 10 years old (Time 1), and their gray matter (GM) volumes were measured using structural Magnetic Resonance Imaging when they were 10- to 14 years old (Time 2). Results After controlling for age, sex, IQ, pubertal stage, and whole-brain volumes, callous-unemotional traits were associated with right-left asymmetry in the medial OFC (mOFC), that is, smaller right mOFC GM as compared to the left. Impulsivity was associated with left-right asymmetry in the mOFC, that is, smaller left mOFC than the right. Narcissism was not associated with any GM asymmetry measure. No significant association was found for the lateral OFC, amygdala, caudate and putamen. Conclusion The present findings provide further support that dimensions of psychopathic traits may have distinct neurobiological correlates.
Type: Peer Reviewed Journal Article
URI: http://hdl.handle.net/20.500.11861/7156
ISSN: 0022-3956
DOI: 10.1016/j.jpsychires.2020.10.003
Appears in Collections:Counselling and Psychology - Publication

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