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Title: Development and validation of a clostridium difficile risk assessment tool
Authors: Smith, Lisa Ann 
Dr. CHAN Chi Keung, Alex 
Halm, Margo 
Slattery, Wendolyn 
Lindquist, Ruth 
Savik, Kay 
Issue Date: 2014
Source: AACN Advanced Critical Care, Oct-Dec 2014, vol. 25(4), pp. 334-346.
Journal: AACN Advanced Critical Care 
Abstract: The incidence of Clostridium difficile infection has increased rapidly during the past decade, increasing lengths of stays in the hospital, costs, and mortality rates. To address this increased incidence, we performed a retrospective case-control study using known risk factors to develop a tool to determine which patients are at risk for infection. Multivariate analysis generated a combination of risk factors associated with development of infection including prior admission, endoscopy within 30 days, cephalosporin/fluoroquinolone use, length of stay 7 days or longer, age 65 years or older, body mass index less than 25, and albumin level less than 2.7 g/dL. A weighted scoring tool was created that predicted disease with a sensitivity of 86% and a specificity of 44% in the derivation sample, and 92% sensitivity and a specificity of 39% when applied to the validation sample. Application of this 8-item tool by nurses in multiple settings could aid in the determination of patients who are at risk, allowing prophylactic treatment, prompt isolation of patients, restricted antibiotic use, and decreased testing of low-risk patients.
Type: Peer Reviewed Journal Article
ISSN: 1559-7768
DOI: 10.1097/NCI.0000000000000046
Appears in Collections:Counselling and Psychology - Publication

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