Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.11861/11007
Title: | Glucagon-like Peptide-1 receptor agonists for the prevention and treatment of Parkinson’s disease |
Authors: | Lee, Serene Yin, Liyang Xiao, Naomi Rhee, Taeho Greg Lo, Heidi K. Y. Wong, Sabrina Fox, Susan Teopiz, Kayla Dr. LAM Yin-Hung, Bess Zheng, Yang Jing Le, Gia Han Mansur, Rodrigo B. Rosenblat, Joshua D. McIntyre, Roger S. |
Issue Date: | 2025 |
Source: | CNS Spectrums, 2025, vol. 30(1), article no. e44. |
Journal: | CNS Spectrums |
Abstract: | Parkinson’s disease (PD) is a severe neurodegenerative disorder characterized by prominent motor and non-motor (e.g., cognitive) abnormalities. Notwithstanding Food and Drug Administration (FDA)-approved treatments (e.g., L-dopa), most persons with PD do not adequately benefit from the FDA-approved treatments and treatment emergent adverse events are often reasons for discontinuation. To date, no current therapy for PD is disease modifying or curative. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are central nervous system (CNS) penetrant and have shown to be neuroprotective against oxidative stress, neuroinflammation, and insulin resistance, as well as promoting neuroplasticity. Preclinical evidence suggests that GLP-1RAs also attenuate the accumulation of α-synuclein. The cellular and molecular effects of GLP-1RAs provide a basis to hypothesize putative therapeutic benefit in individuals with PD. Extant preclinical and clinical trial evidence in PD provide preliminary evidence of clinically meaningful benefit in the cardinal features of PD. Herein, we synthesize extant preclinical and early-phase clinical evidence, suggesting that GLP-1RAs may be beneficial as a treatment and/or illness progression modification therapeutic in PD. |
Type: | Peer Reviewed Journal Article |
URI: | http://hdl.handle.net/20.500.11861/11007 |
ISSN: | 1092-8529 2165-6509 |
DOI: | 10.1017/S109285292510031X |
Appears in Collections: | Counselling and Psychology - Publication |
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