Fan, DiDiFanDong, MaggieMaggieDongDr. ZHANG Xiao, GraceGraceDr. ZHANG XiaoShu, WenjunWenjunShu2026-05-262026-05-262026In Choi, T. M. (Ed.). (2026). Encyclopedia in operations management vol. 1 (pp. 205-213). Academic Press.97804432899419780443289934http://hdl.handle.net/20.500.11861/27249Escalating geopolitical tensions pose significant challenges to global supply chains. This chapter presents an integrative framework to guide firms in managing supply chains amidst heightened uncertainty, focusing on three key dimensions: upstream supplier relationships, supply chain network configuration, and downstream customer relationships. In the upstream dimension, the chapter synthesizes research on strategies such as adaptive supplier adjustment and governance mechanisms to mitigate risks while balancing operational efficiency. For network design, it underscores the importance of balancing efficiency and resilience through approaches like regionalization, localization, and digitalization. The downstream dimension explores the challenges of managing increasingly fragmented customer segments, highlighting the role of corporate sociopolitical activism in aligning brand values with stakeholder expectations. The chapter also identifies gaps in current research and proposes future directions, emphasizing the importance of adaptability, stakeholder alignment, and digital innovation in building resilience. By offering a timely and actionable framework, this chapter advances research in supply chain management and provides practical guidance for firms to navigate the challenges of an increasingly volatile geopolitical environment.enBook Chapter10.1016/B978-0-443-28993-4.00193-1