Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.11861/7601
Title: | Epidemiological and virological characteristics of 2 subgroups of hepatitis B virus genotype C |
Authors: | Chan, Henry L. Y. Tsui, Stephen K. W. Tse, Chi-Hang Ng, Eddie Y. T. Au, Thomas C. C. Yuen, Lilly Bartholomeusz, Angeline Prof. LEUNG Kwong Sak Lee, Kin-Hong Locarnini, Stephen Sung, Joseph J. Y. |
Issue Date: | 2005 |
Source: | Journal of Infectious Diseases, 2005, Vol. 191 (12), pp. 2022 - 2032 |
Journal: | Journal of Infectious Diseases |
Abstract: | Background. We aimed to investigate the characteristics of hepatitis B virus (HBV) genotype C subgroups in Hong Kong and their relationship with HBV genotype C in other parts of Asia. Methods. Full-genome nucleotide sequences of 49 HBV genotype C isolates from Chinese patients with chronic hepatitis B were compared with the sequences of 69 HBV genotype C isolates and 12 non-genotype C isolates in the GenBank database. Phylogenetic analysis was performed to define the subgroups of HBV genotype C on the basis of >4% heterogeneity of the entire HBV genome. Results. HBV in 80% of patients in Hong Kong belonged to a subgroup predominantly found in Southeast Asia (Vietnam, Thailand, Myanmar, and southern China) designated as HBV genotype "Cs," and HBV in the remaining 20% of patients belonged to another subgroup, predominantly found in the Far East (Korea, Japan, and northern China), designated as HBV genotype "Ce." Overall, the mean ± SD nucleotide sequence difference between HBV genotype Cs and HBV genotype Ce was 4.2% ± 0.3%. When HBV genotype Cs and HBV genotype Ce were compared among patients in Hong Kong, HBV genotype Cs was associated with a higher tendency to develop basal core promoter mutations (80% vs. 50%; P = .14), a higher prevalence of C at nucleotide 1858 (95% vs. 0%; P<.001), and a lower prevalence of precore stop codon mutations (5% vs. 50%; P = .002). Conclusions. HBV genotype C can be differentiated into 2 subgroups-namely, genotype Ce and genotype Cs-that have different epidemiological distributions and virological characteristics. © 2005 by the Infectious Diseases Society of America. All rights reserved. |
Type: | Peer Reviewed Journal Article |
URI: | http://hdl.handle.net/20.500.11861/7601 |
ISSN: | 00221899 |
DOI: | 10.1086/430324 |
Appears in Collections: | Publication |
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